Choroidal Melanoma
Collaborative Ocular Melanoma Study Group (COMS), 1990-2006 ⏩
Small n=204, 10y
Study question: Natural history of small choroidal melanomas (0-3mm thick, up to 5mm base). Study Results: 5y related mortality was 1%. 8y related mortality 3.7%.
Medium (2.5-10mm thick, 6-16mm in diameter)
n=1317, 12y+
Study question: Enucleation versus brachytherapy. Study results: Mortality similar in both groups 5y: 19% enucleation vs 18% brachytherapy. Metastatic disease despite tx: 57% enucleated vs 60% Rx.
Large n=1003, 5y+ (more than 10mm thick or 16mm in diameter)
Study question: Enucleation vs external beam rx as adjuvant to enucleation. Study results: No difference in 5y survival. Less local recurrence with additional rx tx.
These studies defined the risk factors for malignant transformation: Thickness >2mm, Fluid-SRF, Symptoms, Orange pigment, Margin < 4 mm from disc, Ultrasound-Hollow, Halo absent on FA, Drusen absent (To Find Small Ocular Melanoma Using-Helpful Hints Daily)
Abbreviations used on this page:
rx-radiation therapy
tx - treatment
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🚧 This page is still being constructed, please feel free to suggest any other trials we should add to this page using the contact us form at the bottom of this page
Small n=204, 10y
Study question: Natural history of small choroidal melanomas (0-3mm thick, up to 5mm base). Study Results: 5y related mortality was 1%. 8y related mortality 3.7%.
Medium (2.5-10mm thick, 6-16mm in diameter)
n=1317, 12y+
Study question: Enucleation versus brachytherapy. Study results: Mortality similar in both groups 5y: 19% enucleation vs 18% brachytherapy. Metastatic disease despite tx: 57% enucleated vs 60% Rx.
Large n=1003, 5y+ (more than 10mm thick or 16mm in diameter)
Study question: Enucleation vs external beam rx as adjuvant to enucleation. Study results: No difference in 5y survival. Less local recurrence with additional rx tx.
These studies defined the risk factors for malignant transformation: Thickness >2mm, Fluid-SRF, Symptoms, Orange pigment, Margin < 4 mm from disc, Ultrasound-Hollow, Halo absent on FA, Drusen absent (To Find Small Ocular Melanoma Using-Helpful Hints Daily)
Abbreviations used on this page:
rx-radiation therapy
tx - treatment
---------------------------------------------------------------------
🚧 This page is still being constructed, please feel free to suggest any other trials we should add to this page using the contact us form at the bottom of this page
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